Tumor microenvironment (TME) is a dynamic area of interest for tumorigenesis and development. Rising proof has make clear the weird position of commensal microbiota within the TME throughout numerous tumors. Microbiota can have long-time exist within the TME and even in tumor cells with out uncontrolled proliferation and deadly an infection to tumor cells, and it might probably work together with tumor cells once they coexist. Particular microbiota can contribute to carcinogenesis by inducing tumor-associated irritation, producing immunosuppressive components, and releasing detrimental metabolites. However much less is understood about how the tumor cells can exert results and modulate the commensal microbiota. On this examine, we discovered that the tumor tissues of sufferers with lung adenocarcinoma have been enriched with Staphylococcus aureus (S. aureus) relative to the adjoining tissues, and the lung cancer-derived exosome-like nanoparticles (ELNs) might be internalized by S. aureus, the remedy of lung cancer-derived ELNs altered the bacterial morphology, decreased the adhesion capacity, biofilm formation and the virulence of S. aureus, the activation of ArlS-ArlR two-component system could also be one of many potential mechanisms beneath the above phenomenon. It’s a novel revelation of the crosstalk between tumor cells and the commensal microbiota.