Two-dimensional supplies have attracted important curiosity and investigation for the reason that marvellous discovery of graphene. As a result of their distinctive bodily, mechanical and optical properties, van der Waals (vdW) supplies possess extraordinary potential for software in future optoelectronics gadgets. Nano-engineering and nano-manufacturing within the atomically skinny regime has additional opened multifarious avenues to discover novel bodily properties. Amongst them, moiré heterostructures, pressure engineering and substrate manipulation have created quite a few unique and topological phenomena similar to unconventional superconductivity, orbital magnetism, versatile nanoelectronics and extremely environment friendly photovoltaics. This assessment comprehensively summarizes the three most influential strategies of nano-engineering in 2D supplies. The newest growth within the marvels of moiré constructions in vdW supplies is mentioned; as well as, topological constructions in layered supplies and substrate engineering on the nanoscale are completely scrutinized to focus on their significance in micro- and nano-devices. Lastly, we conclude with remarks on challenges and attainable future instructions within the quickly increasing subject of nanotechnology and nanomaterial.